Stimulation and measurement patterns versus prior information for fast 3D EIT: A breast screening case study

Imposing prior information is a typical strategy in inverse problems in return for a stable numerical algorithm. For a given imaging system configuration, Picard's stability condition could be deployed as a practical measure of the performance of the system against various priors and noise contaminated measurements. Herein, we make extensive use of this measure to quantify the performance of impedance imaging systems for various injection patterns. In effect, we numerically demonstrate that by varying electrode distributions and numbers, little improvement, if any, in the performance of the impedance imaging system is recorded. In contrast, by using groups of electrodes in the 3D current injection process, a step increase in performance is obtained. Numerical results on a female breast phantom reveal that the performance measure of the imaging system is 15% for a conventional combination of stimulation and prior information, 61% for groups of electrodes and the same prior and 97% for groups of electrodes and a more accurate prior. Finally, since a smaller number of electrodes is involved in the measurement process, a smaller number of measurements is acquired. However, no compromise in the quality of the reconstructed images is observed

Automatic 3D Reconstruction of Coronary Artery Centerlines from Monoplane X-ray Angiogram Images

We present a new method for the fully automatic 3D reconstruction of the coronary artery centerlines, using two X-ray angiogram projection images from a single rotating monoplane acquisition system. During the first stage, the input images are smoothed using curve evolution techniques. Next, a simple yet efficient multiscale method, based on the information of the Hessian matrix, for the enhancement of the vascular structure is introduced. Hysteresis thresholding using different image quantiles, is used to threshold the arteries. This stage is followed by a thinning procedure to extract the centerlines. The resulting skeleton image is then pruned using morphological and pattern recognition techniques to remove non-vessel like structures. Finally, edge-based stereo correspondence is solved using a parallel evolutionary optimization method based on f symbiosis. The detected 2D centerlines combined with disparity map information allow the reconstruction of the 3D vessel centerlines. The proposed method has been evaluated on patient data sets for evaluation purposes

Connectivity and coverage in machine-type communications

Machine-type communication (MTC) provides a potential playground for deploying machine-to-machine (M2M), IP-enabled 'things' and wireless sensor networks (WSNs) that support modern, added-value services and applications. 4G/5G technology can facilitate the connectivity and the coverage of the MTC entities and elements by providing M2M-enabled gateways and base stations for carrying traffic streams to/from the backbone network. For example, the latest releases of long-term evolution (LTE) such as LTE-Advanced (LTE-A) are being transformed to support the migration of M2M devices. MTC-oriented technical definitions and requirements are defined to support the emerging M2M proliferation. ETSI describes three types of MTC access methods, namely a) the direct access, b) the gateway access and c) the coordinator access. This work is focused on studying coverage aspects when a gateway access takes place. A deployment planar field is considered where a number of M2M devices are randomly deployed, e.g., a hospital where body sensor networks form a M2M infrastructure. An analytical framework is devised that computes the average number of connected M2M devices when a M2C gateway is randomly placed for supporting connectivity access to the M2M devices. The introduced analytical framework is verified by simulation and numerical results

Connectivity and coverage in machine-type communications

Machine-type communication (MTC) provides a potential playground for deploying machine-to-machine (M2M), IP-enabled 'things' and wireless sensor networks (WSNs) that support modern, added-value services and applications. 4G/5G technology can facilitate the connectivity and the coverage of the MTC entities and elements by providing M2M-enabled gateways and base stations for carrying traffic streams to/from the backbone network. For example, the latest releases of long-term evolution (LTE) such as LTE-Advanced (LTE-A) are being transformed to support the migration of M2M devices. MTC-oriented technical definitions and requirements are defined to support the emerging M2M proliferation. ETSI describes three types of MTC access methods, namely a) the direct access, b) the gateway access and c) the coordinator access. This work is focused on studying coverage aspects when a gateway access takes place. A deployment planar field is considered where a number of M2M devices are randomly deployed, e.g., a hospital where body sensor networks form a M2M infrastructure. An analytical framework is devised that computes the average number of connected M2M devices when a M2C gateway is randomly placed for supporting connectivity access to the M2M devices. The introduced analytical framework is verified by simulation and numerical results

Ultra-Low-loss Reconfigurable Phase-shifting Metasurface in V band:A Multi-objective Optimization Approach

Future generations of satellite and mobile communications at mm-wave frequencies require the use of low-loss and wideband phase-shifting components. Pixelated metasurfaces provide large design versatility and constitute an attractive solution for wave manipulation, such as shifting the phase of an incident wave. However, their design often implies the simultaneous tuning of a large number of geometrical parameters. This article employs an enhanced multi-objective optimization algorithm to design a dynamically reconfigurable metasurface providing ultra-low losses and linear phase response. The presented methodology can be easily employed for different objective functions or technologies, constituting a versatile design strategy for electromechanically reconfigurable devices based on pixelated metasurfaces. A prototype is fabricated based on the optimization outcome, achieving a phase shifter capable of providing a continuous phase shift up to 180∘ between 50 and 65 GHz. A piezo-electric actuator is used to dynamically adjust the phase shift with respect to the position of a metallic ground plane placed in front of the metasurface. A linear evolution of the phase w.r.t. the ground plane displacement is obtained while maintaining the losses around 1 dB for the whole frequency range

Vitamin B12 supplementation in diabetic neuropathy: a 1-year, randomized, double-blind, placebo-controlled trial

Aim: To investigate the effect of normalizing vitamin B12 (B12) levels with oral B12 (methylcobalamin) 1000 μg/day for one year in patients with diabetic neuropathy (DN). Patients and methods: In this prospective, double-blind, placebo-controlled trial, 90 patients with type 2 diabetes on metformin for at least four years and both peripheral and autonomic DN were randomized to an active treatment group (n = 44) receiving B12 and a control group (n = 46) receiving a placebo. All patients had B12 levels less than 400 pmol/L. Subjects underwent measurements of sural nerve conduction velocity (SNCV), sural nerve action potential (amplitude) (SNAP), and vibration perception threshold (VPT), and they performed cardiovascular autonomic reflex tests (CARTs: mean circular resultant (MCR), Valsalva test, postural index, and orthostatic hypotension). Sudomotor function was assessed with the SUDOSCAN that measures electrochemical skin conductance in hands and feet (ESCH and ESCF, respectively). We also used the Michigan Neuropathy Screening Instrument Questionnaire and Examination (MNSIQ and MNSIE, respectively) and questionnaires to evaluate quality of life (QoL) and level of pain (pain score). Results: B12 levels increased from 232.0 ± 71.8 at baseline to 776.7 ± 242.3 pmol/L at follow-up, p < 0.0001, in the active group but not in the control group. VPT, MNSIQ, QoL, pain score, SNCV, SNAP, and ESCF significantly improved in the active group (p < 0.001, p = 0.002, p < 0.0001, p < 0.000, p < 0.0001, p < 0.0001, and p = 0.014, respectively), whereas CARTS and MNSIE improved but not significantly. MCR, MNSIQ, SNCV, SNAP, and pain score significantly deteriorated in the control group (p = 0.025, p = 0.017, p = 0.045, p < 0.0001, and p < 0.0001, respectively). Conclusions: The treatment of patients with DN with 1 mg of oral methylcobalamin for twelve months increased plasma B12 levels and improved all neurophysiological parameters, sudomotor function, pain score, and QoL, but it did not improve CARTS and MNSIE

Participatory citizenship: critical perspectives on client-centred occupational therapy

Background/aims: This article aims to discuss client-centred practice, the current dominant approach within occupational therapy, in relation to participatory citizenship. Occupational therapists work within structures and policies that set boundaries on their engagement with clients, while working with complex, multidimensional social realities. Methods: The authors present a critical discussion shaped by their research, including a survey, discussions at workshops at international conferences, and critical engagement with the literature on occupational therapy, occupation, and citizenship. Conclusion: A focus on citizenship suggests reframing professional development based on the participation in public life of people as citizens of their society. While occupational therapists often refer to clients in the context of communities, groups, families, and wider society, the term client centred practice typically represents a particular view of the individual and may sometimes be too limited in application for a more systemic and societal approach. Significance: The authors question the individual focus which has, until recently, been typical of client-centred occupational therapy. Placing citizenship at the core of intervention is a transformative process that assumes all people are citizens and conceives of health as a collective issue, influencing the way we educate, do research, and practise. Key words: Collective, dis-citizenship, inequalities, professional development, participation, paradigms, occupational justice</p

XR-RF Imaging Enabled by Software-Defined Metasurfaces and Machine Learning: Foundational Vision, Technologies and Challenges

We present a new approach to Extended Reality (XR), denoted as iCOPYWAVES, which seeks to offer naturally low-latency operation and cost-effectiveness, overcoming the critical scalability issues faced by existing solutions. iCOPYWAVES is enabled by emerging PWEs, a recently proposed technology in wireless communications. Empowered by intelligent (meta)surfaces, PWEs transform the wave propagation phenomenon into a software-defined process. We leverage PWEs to i) create, and then ii) selectively copy the scattered RF wavefront of an object from one location in space to another, where a machine learning module, accelerated by FPGAs, translates it to visual input for an XR headset using PWEdriven, RF imaging principles (XR-RF). This makes for an XR system whose operation is bounded in the physical layer and, hence, has the prospects for minimal end-to-end latency. Over large distances, RF-to-fiber/fiber-to-RF is employed to provide intermediate connectivity. The paper provides a tutorial on the iCOPYWAVES system architecture and workflow. A proof-of-concept implementation via simulations is provided, demonstrating the reconstruction of challenging objects in iCOPYWAVES produced computer graphics

Decolonising occupational science education through learning activities based on a study from the Global South

If occupational science education is to become more globally relevant, it must highlight more voices and practices from diverse communities. Learning about occupational justice from the perspectives of Global South communities addresses cognitive injustice and the need to decolonise occupational science education. This paper offers some critical reflections concerning the author’s pedagogic approach, and the ways his research about olive growing in Palestine (Simaan, 2018) informed students’ learning about occupational justice. It focuses on the processes in which students and lecturers engaged within a decolonising approach to occupational science education. A learning activity based on pedagogical processes of ‘conscientization’ (Freire, 1996), critical reflexivity (Whiteford & Townsend, 2011) and intercultural translation (Santos, 2014) is discussed, and lessons learnt by lecturer and students about themselves, their communities, and occupational science are reflected upon. Selected students’ reflections, which illustrate how they positioned themselves in relation to the community studied, and how they interrogated their own reactions to learning about daily lives in Palestine, are discussed. These processes demonstrate the benefits of highlighting local knowledge on occupational justice produced by Global South groups, and how this knowledge might begin to address cognitive injustice and the need to decolonise occupational science pedagogy. More empirical and theoretical work is needed in occupational science education regarding intercultural translations concerning occupational justice, and means of doing and knowing from diverse Global South perspectives

Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease

<p>Abstract</p> <p>Background</p> <p>In a genome-wide association scan, the single-nucleotide polymorphism (SNP) rs738409 in the patatin-like phospholipase 3 gene (<it>PNPLA3</it>) was strongly associated with increased liver fat content. We investigated whether this SNP is associated with the occurrence and progression of nonalcoholic fatty liver disease (NAFLD) in the Japanese population.</p> <p>Methods</p> <p>SNP rs738409 was genotyped by the Taqman assay in 253 patients with NAFLD (189 with nonalcoholic steatohepatitis [NASH] and 64 with simple steatosis) and 578 control subjects. All patients with NAFLD underwent liver biopsy. Control subjects had no metabolic disorders. For a case-control study, the <it>χ</it>²-test (additive model) was performed. Odds ratios (ORs) were adjusted for age, gender, and body mass index (BMI) by using multiple logistic regression analysis with genotypes (additive model), age, gender, and BMI as the independent variables. Multiple linear regression analysis was performed to test the independent effect of risk allele on clinical parameters while considering the effects of other variables (age, gender, and BMI), which were assumed to be independent of the effect of the SNP.</p> <p>Results</p> <p>The risk allele (G-allele) frequency of rs738409 was 0.44 in the control subjects and 0.60 in patients with NAFLD; this shows a strong association with NAFLD (additive model, <it>P </it>= 9.4 × 10^-10). The OR (95% confidence interval) adjusted for age, gender, and BMI was 1.73 (1.25-2.38). Multiple linear regression analysis indicated that the G-allele of rs738409 was significantly associated with increases in aspartate transaminase (AST) (<it>P </it>= 0.00013), alanine transaminase (ALT) (<it>P </it>= 9.1 × 10^-6), and ferritin levels (<it>P </it>= 0.014), and the fibrosis stage (<it>P </it>= 0.011) in the patients with NAFLD, even after adjustment for age, gender, and BMI. The steatosis grade was not associated with rs738409.</p> <p>Conclusions</p> <p>We found that in the Japanese population, individuals harboring the G-allele of rs738409 were susceptible to NAFLD, and that rs738409 was associated with plasma levels of ALT, AST, and ferritin, and the histological fibrosis stage. Our study suggests that <it>PNPLA3 </it>may be involved in the progression of fibrosis in NAFLD.</p